Future explorers take note. Applicants must be resilient, adaptable, resourceful and must work well within a team. The whole project will be televised, from the reality TV style selection process, to landing and beyond.
But is it realistic to believe that individuals could live and prosper on the Red Planet?
On Earth, we are protected from the solar wind by a strong magnetic field. Without this, it would be much more difficult to survive. Although Mars once had similar protection about four billion years ago, today there is no such shield protecting it.
To minimise radiation, the project team will cover the domes with several metres of soil, which the colonists will have to dig up.
"They [the applicants] will be told that there are risks, but it will be our responsibility to keep the risks within acceptable odds."
Nasa astronaut Stan Love knows first-hand the difficulties with technology that his colleagues have experienced on the International Space Station in low-Earth orbit.
The apparatus which recycles human waste and turns "yesterday's coffee into into tomorrow's coffee needs frequent maintenance and would likely not survive years of continuous duty on Mars", he says.
Love has recently returned from Antarctica which he says is a "picnic compared to Mars".
"It's full of water, you can go outside and breathe the air. It's paradise compared to Mars and yet nobody has moved there permanently."
Although dubious about the funding, the technology and the impact of radiation, Love applauds small enterprises like Mars One.
He strongly believes private organisations will help raise awareness and hopefully discover or design some technology which will help future teams reach their goal of landing on Mars.
"We've been dreaming about this for 50 years. The Moon was just supposed to be a stepping stone to Mars. But when you study the problem, you realise it's immensely hard to do this."
Many critics have focused on funding, and whether the project would hold the public's attention for many years. It will cost an estimated £3.8bn ($6bn) to send the first group.
Dr Chris Lintott from Oxford University says that while the project is technologically plausible, he does not think they will find the funding.
"It's about having the political will and the financial muscle to make this happen. That's what nobody has been able to solve so far," he explains.
But Lansdorp sees no issue with funding. He uses the revenue from the worldwide broadcasting rights of the Olympics as a comparison.
"This will be the biggest thing that humanity has ever done. In 15 years people will still be watching.
"Exploring our world, and now beyond is what humans do, it's in our genome. The settlers' dream of going to Mars will come true."
Whether or not the mission will achieve its goal, the publicity generated from the "big-brother" style televised application process means the world will surely be watching.